Custom Chemical Synthesis

Nanomaterials · Metal Precursors · Specialty Ligands · Polymer Additives · Surface Agents

Neo Materials R&D synthesises custom functional chemicals on demand — from gram-scale proof-of-concept to kilogram-scale production batches. Every compound is characterised by ¹H/¹³C NMR, HRMS, HPLC purity analysis, and TGA/DSC thermal profiling. Full Certificate of Analysis (CoA) with each batch.

99.9%

HPLC Purity

NMR + MS

Verification

1g–5kg

Batch Scale

CoA Issued

Every Batch

Submit Synthesis Request Explore Chemistry ↓

CHEMICAL SYNTHESIS LABORATORY

Custom Chemicals: 10-Module Technical Tour

Synthesis capabilities, nanomaterials, metal precursors, characterisation suite, analytical data, and ordering process.

Custom Organic & Inorganic Synthesis

Neo Materials R&D performs multi-step organic synthesis including Suzuki coupling, Grignard reaction, reductive amination, and RAFT polymerisation. Inorganic synthesis includes co-precipitation, sol-gel, hydrothermal synthesis, and CVD precursor preparation. All reactions under inert atmosphere (Schlenk line / glove box) when required.

Organic reactionsSuzuki, Heck, Grignard, reductive Am.

Inorganic routesCo-ppt., sol-gel, hydrothermal, CVD

Scale range0.1 g – 5 kg per batch

Atmosphere controlSchlenk line / MBraun glove box

Temperature range-78°C (cryo) to 350°C

Pressure reactorsUp to 200 bar (Parr vessel)

Custom Nanomaterials

Controlled synthesis of metallic nanoparticles (Au, Ag, Pd, Pt), quantum dots (CdSe, ZnS), metal oxide nanoparticles (TiO₂, ZnO, Fe₃O₄), and carbon nanomaterials (graphene oxide, CNT functionalised). Size control by ligand concentration and temperature; characterised by TEM, DLS, XRD, and XPS.

Gold NPs5–100 nm (citrate / CTAB)

Silver NPs10–80 nm (polyol method)

Fe₃O₄ NPs8–20 nm (co-precipitation)

TiO₂ (anatase)10–25 nm (sol-gel, 450°C calcine)

Quantum dotsCdSe/ZnS, λ = 490–680 nm

CharacterisationTEM + DLS + XRD + FTIR

Metal Precursors & Coordination Compounds

CVD/ALD metal precursors, MOCVD source materials, and organometallic coordination compounds for thin-film deposition and catalysis. Synthesised under strict anhydrous conditions with rigorous purity verification by ICP-MS metal analysis and ¹H NMR ligand verification.

Compound	Application	Purity	Scale	Storage
Ti(OiPr)₄	TiO₂ ALD precursor	99.9%	100g–1kg	-20°C, N₂
Pd(OAc)₂	Suzuki catalyst	99.5%	1g–100g	RT, dark
HAuCl₄·3H₂O	Au NP synthesis	99.9% Au	1g–50g	4°C, dark
Cp₂ZrCl₂	Ziegler-Natta poly	98%	5g–500g	RT, inert
RuCl₃·xH₂O	DSSCs, HER catalyst	99.9% Ru	1g–50g	RT, sealed
Bi(NO₃)₃·5H₂O	BiVO₄ photocatalyst	99.5%	50g–2kg	RT, dry

Specialty Ligands & Chelating Agents

Custom phosphine ligands, N-heterocyclic carbenes (NHCs), salen complexes, and bis-oxazoline (BOX) chiral ligands for asymmetric catalysis. Chelating agents for metal extraction, remediation, and MRI contrast agent development. All compounds characterised by ³¹P NMR (phosphines), ¹H/¹³C NMR, and single-crystal X-ray when possible.

🔵 Phosphine Ligands

PPh₃, dppe, dppp, BINAP (±), XPhos, SPhos — designed for Pd, Ni, Rh catalysis. σ-donors modulate metal electron density. Cone angle controls steric hindrance. Custom bite-angle bisphosphines available.

🟣 NHC Carbenes

Imidazol-2-ylidene and benzimidazol-2-ylidene NHC ligands for stable, highly active metal catalysts. IPr, IMes, SIPr available. Strong σ-donors; minimal π-backbonding. Custom wingtip groups synthesised.

🟤 Salen & Schiff Base

N₂O₂ tetradentate salen ligands (Jacobsen type) for asymmetric epoxidation and ring opening. Custom substitution at 3,3' positions for sterics; enantioselectivity >90% ee achievable.

🔴 EDTA Analogues

DTPA, DOTA, NOTA, TETA macrocyclic chelators for MRI contrast agents (Gd³⁺ complexes), nuclear medicine (⁶⁴Cu, ⁶⁸Ga PET), and heavy metal remediation from wastewater.

Polymer Additives & Functional Monomers

Custom synthesis of polymerisable monomers, cross-linkers, chain transfer agents (RAFT), and photo-initiators. Also functional additives: antioxidants, UV stabilisers (HALS), flame retardants (phosphorus-based), and nucleating agents. All designed to be compatible with specific polymer matrices (PP, PE, PET, epoxy, polyurethane).

RAFT agentsTrithiocarbonate, dithioester

Photo-initiatorsType I (Norrish) / Type II

HALS UV stabiliserHindered amine (piperidine)

Flame retardantDOPO derivatives (P-based)

Nucleating agentSorbitol acetal (Millad)

Cross-linkersEGDMA, TPGDA, DVB, PEGDA

RAFT POLYMERISATION

Reversible Addition-Fragmentation Chain Transfer (RAFT) enables precise control of molecular weight and dispersity (Đ < 1.1):
Rn• + S=C(Z)-SR' ⇌ Rn-S-C•(Z)-SR'
Target Mn = [M]₀/[CTA]₀ × M_M × conversion
Neo synthesises custom RAFT agents (CTA) with specific Z and R groups to match any monomer class: acrylate, acrylamide, styrenic, vinyl ester.

Surface Modification & Coupling Agents

Silane coupling agents, thiols for gold surface modification, phosphonic acids for metal oxide surfaces, and polyelectrolyte coatings for nanoparticle stabilisation. Custom synthesis of bifunctional molecules with one reactive group toward the substrate and one toward the target polymer/drug/biomolecule.

🔗 Silane Coupling Agents

APTES (amine), MPTMS (thiol), TMSPM (methacrylate), GPTMS (epoxy) silanes. Hydrolysis to silanol → covalent Si-O-Si bond to SiO₂, glass, TiO₂. Custom spacer lengths (C3–C11) available.

🥇 Gold Thiol SAMs

Self-assembled monolayer (SAM) thiols for Au NP and Au substrate functionalisation. ω-functional thiols: HS-(CH₂)n-X where X = OH, NH₂, COOH, biotin, PEG. Custom chain length and terminal group.

🔵 Phosphonic Acids

R-PO(OH)₂ bidentate anchors for TiO₂, ZrO₂, and Al₂O₃ surfaces. Applications: DSSC dye anchoring, corrosion inhibitors, biocompatible NP coatings. 11-phosphonoundecanoic acid and custom variants.

🟢 PEG Conjugates

Heterobifunctional PEG: NHS-PEG-maleimide, COOH-PEG-NH₂, biotin-PEG-azide for click chemistry. Mn 1000–10,000 Da. Low dispersity (Đ < 1.05). Critical for NP stealth and targeted drug delivery.

Full Characterisation Suite

Every custom chemical batch is characterised by a suite of analytical techniques before release. Certificate of Analysis (CoA) contains: HPLC purity trace, NMR spectra (with peak assignment), HRMS exact mass, and where relevant — TGA, DSC, XRD, TEM, DLS, and BET surface area.

📊 HPLC Purity

Reverse-phase C18 column, UV/DAD detector. Purity ≥99% area. Retention time and peak area reported. Impurity profile below 0.1% LOQ. Gradient method developed for each compound class.

🔬 NMR Spectroscopy

¹H, ¹³C, ³¹P, ¹⁹F, COSY, HSQC, HMBC available (400 MHz Bruker Avance). Complete structural assignment with integration ratios. Solvent: CDCl₃, DMSO-d₆, D₂O, CD₂Cl₂.

⚖ HRMS Exact Mass

ESI-HRMS (Bruker maXis) for [M+H]⁺, [M+Na]⁺, [M-H]⁻ exact mass. Accuracy <5 ppm. Confirms molecular formula unambiguously. Isotope pattern matching. Essential for novel compounds.

🌡 TGA/DSC

Thermal gravimetric analysis (TA Q500) for decomposition temperature (T_d), moisture content, solvent residue. DSC (TA Q200) for melting point (T_m), crystallisation, glass transition (T_g).

📐 XRD & TEM

Powder XRD (Rigaku Ultima IV) for crystal phase identification and crystallite size (Scherrer equation). TEM (JEOL JEM-2100) for nanoparticle morphology and size distribution histogram.

💧 DLS & BET

Dynamic Light Scattering (Malvern Zetasizer) for hydrodynamic diameter (Z-average) and ζ-potential of nanoparticle suspensions. BET N₂ adsorption (Micromeritics) for surface area of porous materials.

Sample NMR & MS Data

Illustrative data format for a synthesised biaryl compound (Suzuki product). This is representative of the characterisation package provided with every custom synthesis order. Data is delivered as PDF with raw instrument files (JCAMP-DX, mzXML).

Compound4-Methoxybiphenyl

MW184.23 g/mol

CAS838-95-9

HPLC purity99.7% (220 nm)

HRMS [M+H]⁺185.0966 (calc. 185.0966)

Yield92% (Suzuki, Pd(PPh₃)₄)

Safety, Storage & Regulatory Compliance

All custom chemical shipments include a full Safety Data Sheet (SDS) per GHS/UN, appropriate UN hazard class labelling, and storage/handling instructions. Export-controlled compounds are shipped only with verified end-user declarations per applicable regulations (REACH, RoHS, TSCA).

SDS standardGHS Rev. 9 (UN-GHS)

PackagingUN-approved bottles/drums

LabellingGHS pictograms + H/P statements

RegulatoryREACH / RoHS / TSCA verified

Cold chain2–8°C insulated packaging

Shelf life12–36 months (compound-dependent)

STORAGE CLASSES (GHS)

SC 3: Flammable liquids (flash pt <23°C)
SC 4.1A: Oxidising solids
SC 6.1A: Acutely toxic (oral LD₅₀ <5 mg/kg)
SC 8A: Corrosive materials
SC 10: Combustible solids
SC 13: Non-hazardous solids/liquids
Incompatible classes stored separately. Full MSDS risk assessment provided.

How to Order Custom Synthesis

Neo Materials makes custom synthesis ordering straightforward. Submit your structure (SMILES, CAS, or paper reference), specify purity, quantity, and delivery requirements. We provide a feasibility assessment and quote within 48 hours.

ORDER PROCESS

Step 1Submit SMILES / structure + specs

Step 2Neo feasibility assessment (48 h)

Step 3Commercial quote + route proposal

Step 4PO + milestone payment (50% upfront)

Step 5Synthesis + QC characterisation

Step 6CoA + compound delivered

WHAT TO INCLUDE IN REQUEST

✔ Compound SMILES or CAS number
✔ Target purity (e.g. ≥99% HPLC)
✔ Required quantity (g or kg)
✔ Delivery timeline requirement
✔ Required characterisation (NMR? MS?)
✔ Application context (if possible)
✔ Regulatory requirements (REACH, etc.)
✔ Storage/shipping temperature

Request a Custom Synthesis

Send us your structure (SMILES, CAS, or literature reference), desired purity, and quantity — we respond with a feasibility assessment and quote within 48 hours.

Submit Synthesis Enquiry